Therapeutic effects of ginseng and its major components on ischaemic stroke in vitro and in silico.

ABSTRACT:

Background

Ischemic stroke (IS) poses a significant threat to human health, prompting the need for more effective treatments. Tianjiangxueshuantong (TJXST) pills, commonly used for cerebrovascular diseases, contain ginseng, whose therapeutic potential for IS remains underexplored. This study investigates the effects and mechanisms of ginseng in IS.

Methods

Initially, we established oxygen-glucose deprivation/reperfusion (OGD/R) models using bEnd.3 cells and glutamate-induced injuries in PC12 cells to assess the effects of ginseng extracts on cell activity using CCK8 assays. Subsequently, we employed network pharmacology in conjunction with the GEO database to identify the core active components of ginseng, key intervention targets in IS, and potential signaling pathways. We

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12645755 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature