Integrated scRNA-seq and transcriptome analyses uncover the effects of UBE2H on the immune microenvironment regulation in pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer, recognized as a refractory tumor, has an overall survival rate of less than 10%, and its mortality rate continues to rise. Due to the low immune activity induced by its unique tumor microenvironment, pancreatic cancer is classified as a "cold" tumor and is insensitive to current immunotherapies. However, little is still known about the identification and functional mechanisms of key regulatory molecules in the formation of "cold" tumors.

Methods

In this study, we identified the pancreatic ductal cell niche through single-cell sequencing. By calculating CNV scores using inferCNV to distinguish malignant from non-malignant cells and analyzing differences in transcriptional levels, we constructed a 15-gene model. The inhibitory effect of UBE2H on t

SUBMITTER: Huang F 

PROVIDER: S-EPMC12645782 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature