Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue-specific interactomes and regulatory macromolecular assemblies, offers a promising avenue to elucidate altered disease pathways. In this study, we applied differential interactome analysis using a manually curated AD dataset to identify how disease-associated mutations alter both transient and stable protein interactions. By focussing on variant-specific associations detected in brain-relevant tissues, we mapped disruptions in stable macromolecular assemblies and performed Reactome

SUBMITTER: Panneerselvam K 

PROVIDER: S-EPMC12645816 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature