The probiotic <i>Limosilactobacillus fermentum</i> CECT5716 enhances the antihypertensive response to hydrochlorothiazide in spontaneously hypertensive rats.

ABSTRACT: Limosilactobacillus fermentum CECT5716 (LC40) consumption reduces hypertension and improves endothelial dysfunction in spontaneously hypertensive rats (SHRs). The diuretic hydrochlorothiazide (HCTZ) lowers blood pressure in SHR but disrupts the gut microbiota balance. In this study, we investigated whether the LC40 could enhance the antihypertensive effects of HCTZ. Interestingly, we found that coadministration of LC40 with HCTZ potentiated the beneficial effects of HCTZ on endothelial dysfunction and blood pressure without altering plasma HCTZ concentrations or exacerbating electrolyte imbalances. These protective effects were associated with normalization of microbiota alterations, including a reduction in the Firmicutes/Bacteroidota ratio, suppression of lipopolysaccharide biosyn

SUBMITTER: Gonzalez-Correa C 

PROVIDER: S-EPMC12645898 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature