Analysis of Teg41 and PSMα promoter activity using a divergent fluorescent reporter plasmid.

ABSTRACT: Staphylococcus aureus is a common commensal of human skin and anterior nares but also a notable pathogen, causing a range of diseases from minor skin infections to serious, often fatal conditions. The global health community considers S. aureus a serious threat due to the rise of multidrug-resistant strains, including community-acquired methicillin-resistant S. aureus. Effective host tissue invasion by S. aureus requires precise spatiotemporal regulation of virulence factor expression, which can be controlled by small RNAs (sRNAs). Our lab has identified over 300 potential sRNAs in S. aureus USA300, highlighting their regulatory significance. Recently, our group characterized an sRNA named Teg41, which positively influences transcription from the PSMα pro

SUBMITTER: Briaud P 

PROVIDER: S-EPMC12645910 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature