CLL, together with C1qR, suppresses WSSV infection by regulating the activation of Dorsal.

ABSTRACT: There is no evidence that arthropods possess a complement system. In arthropods, only gC1qR has been reported. The functional convergence of gC1qR in arthropods and vertebrates during evolution remains to be further elucidated. In the present study, a C-type lectin named PcCLL, which contains a C1q-like sequence (a segment of the C1q globular head) and might be involved in antiviral immunity, was identified in Procambarus clarkii. When crayfish are infected with white spot syndrome virus (WSSV), some C1qRs (gC1qR homologs), which are located at the cell membrane, recognize WSSV by interacting with the envelope protein VP28. Subsequently, C1qR recruits PcCLL in the cell, and the C1qR-PcCLL complexes synergistically promote the nuclear translocation of Dorsal. Ser

SUBMITTER: Cao X-T 

PROVIDER: S-EPMC12645952 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature