Modeling immune responses of cattle to <i>Mycobacterium bovis</i> using magnetic bioprinted granulomas.

ABSTRACT: Tuberculosis (TB) remains a threat for human and livestock health. Mycobacteria causing TB are host-adapted pathogens that occasionally spill over into other species. Mycobacterium bovis causes bovine TB, a well-known zoonosis. Mycobacterium tuberculosis is adapted to humans and can occasionally trigger symptomatic infection in cattle. However, immunocompetent cattle are resistant to experimental infection with M. tuberculosis. Hallmarks of TB in susceptible hosts are organized multicellular tissue lesions termed granulomas. In the absence of suitable in vitro systems that enable investigations of bovine tuberculous granuloma, we developed a three-dimensional granuloma model using bovine leukocytes and magnetic cell labeling. This model was termed the in vitr

SUBMITTER: Krueger G 

PROVIDER: S-EPMC12645956 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature