Niacin, an active form of vitamin B3, exerts antiviral function by recruiting β-arrestin through GPR109A to activate the phosphorylation of ERK and STAT1 axis.

ABSTRACT: The emergence of viral infectious diseases poses a significant threat to public health, and thus the development of effective and safe antiviral drugs is becoming an urgent priority in the pandemic era. Niacin is an active form of vitamin B3 and has been used for hyperlipidemia treatment for decades, with well-established safety and pharmacological profiles. In this study, niacin was found to be a promising antiviral agent with both nutritional and therapeutic benefits. Further data showed that niacin could bind to its receptor GPR109A and then recruit β-arrestin to promote the ERK-STAT phosphorylation axis, subsequently leading to the activation of interferon signaling. Therefore, these findings provided evidence for repurposing this well-established drug as an antiviral agent and also hi

SUBMITTER: Li S 

PROVIDER: S-EPMC12645984 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature