<i>APOE</i> genotype and sex drive microbiome divergence after microbiome standardization in <i>APOE</i>-humanized mice.

ABSTRACT: The APOE4 allele is the greatest known genetic factor for sporadic or late-onset Alzheimer's Disease (LOAD). Gut microbiome (GMB) dysbiosis can lead to poorer outcomes in disease. The intersection of sex, APOE genotype, inflammation, and gut microbiota is incompletely understood. Previous studies in humans and humanized APOE mice have demonstrated APOE-genotype-specific differences in the GMB. However, most of these studies were unable to resolve bacteria to the species level. It remains unclear how GMB changes with age and sex in the context of APOE genotype. In this study, humanized male mice with either APOE 2, 3, or 4 genotype were bred with the same two C57BL/6J sisters to standardize microbiomes across lines and monitor divergence based on

SUBMITTER: Aries Marchington M 

PROVIDER: S-EPMC12645986 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature