Childhood trauma and subclinical hypomania in early adulthood: A genetically informative study.

ABSTRACT:

Background

There is preliminary evidence that childhood trauma (e.g., abuse) is associated with subclinical hypomania reported in adolescence. These findings need replicating in early adulthood, as clinical conditions emerge, and the mechanisms underlying this association need elucidating. This study aimed to examine the magnitude of shared genetic and environmental underpinnings of the association between childhood trauma with hypomanic symptoms and high-risk status for bipolar disorder (BD) using a twin design. Gene-environment correlations and interactions between childhood trauma and polygenic scores (PGS) for psychiatric and neurodevelopmental conditions were also investigated.

Methods

Childhood trauma was reported using the Avon "Life at 22+" questionnaire by 8,464 ind

SUBMITTER: Gonzalez-Calvo I 

PROVIDER: S-EPMC12646032 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature