Complement receptor <i>C3ar1</i> deficiency does not alter brain structure or functional connectivity across early life development.

ABSTRACT: Genetic deletion of the complement C3a anaphylatoxin chemotactic receptor (C3ar1), a key component of the innate immune response, is reported to induce behavioural phenotypes resembling anxiety and hyperactivity in mice, suggesting a neurodevelopmental role for this gene in health. However, it is not currently clear when and where C3ar1 is needed in the brain, which is further complicated by the fact that C3ar1 is expressed predominantly by microglia and therefore does not localize to specific brain regions, warranting exploratory and brain-wide assessment through neuroimaging. Resolving when and where C3ar1 is needed are questions of significant translational importance because, as a G-protein-coupled receptor, human C3AR1 serves as a potential therapeutic targ

SUBMITTER: Lemmik H 

PROVIDER: S-EPMC12646079 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature