Immunostimulatory Pickering emulsion for oral vaccine delivery.

ABSTRACT: To overcome gastric acid degradation and ensure robust immune activation, a novel Pickering emulsion stabilized by poly(lactic-co-glycolic acid) (PLGA) nanoparticles was developed for the co-delivery of vaccine antigens and adjuvants via the oral route. Pickering emulsions, stabilized by solid particles, can enhance stability and protect antigens from gastric degradation. We encapsulated a TLR7/8 agonist R848 in PLGA nanoparticles and fabricated Pickering emulsions (R848-PLGA-NP@PE) to boost immune activation, and further prepared model antigen Ovalbumin (OVA) loaded Pickering emulsion formulation (R848-PLGA-NP@PE-OVA) to induce antigen-specific immune responses. R848-PLGA-NPs can improve vaccine efficacy by serving both as a stabilizer and an adjuvant, activating antigen-presenting cells

SUBMITTER: Xie J 

PROVIDER: S-EPMC12646106 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature