Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders.

ABSTRACT:

Background

A better mechanistic understanding of schizophrenia spectrum disorders is crucial to developing efficient treatment approaches. Therefore, this study investigated longitudinal interrelations between clinical outcomes, brain structure, and somatic health in post-acute individuals from the schizophrenia spectrum.

Methods

A sample of 63 post-acute patients from two independent physical exercise studies was included in the final analyses. Demographic, clinical, cognitive, and somatic data were acquired at baseline and follow-up, as were structural magnetic resonance imaging scans. Multivariate cross-lagged panel modeling including mediators was used to study the mutual interrelations over time between the clinical, neural, and somatic levels.

Results

A higher b

SUBMITTER: Roell L 

PROVIDER: S-EPMC12646119 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature