OpTiles: an R package for adaptive tiling and methylation variability profiling.

ABSTRACT:

Summary

OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG density with intra-region methylation variability, it provides a reliability metric and extended functionality for annotating, prioritizing, and interpreting complex methylation data.

Availability and implementation

OpTiles is implemented in R and source code is freely available at https://github.com/fhaive/OpTiles. Data are available on Zenodo at https://doi.org/10.5281/zenodo.16961292.

SUBMITTER: Migliaccio G 

PROVIDER: S-EPMC12646143 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature