Membrane-localized MET engages PVR to mediate extranuclear juvenile hormone signaling in <i>Aedes aegypti</i>.

ABSTRACT: Although Methoprene-tolerant (MET) is well established as the intracellular receptor mediating the genomic actions of juvenile hormone (JH) in insects, the identity of the receptor responsible for initiating extranuclear JH responses has remained elusive. In the yellow fever mosquito Aedes aegypti, we identify the platelet-derived growth factor- and vascular endothelial growth factor-receptor related (PVR) protein as a key mediator of membrane-initiated JH signaling. JH treatment induces robust PVR phosphorylation in the fat body of adult female mosquitoes. Disruption of PVR function suppresses JH-induced activation of the phospholipase C and phosphatidylinositol 3-kinase signaling pathways and impairs primary follicle growth during the previtellogenic stage. Strikingly, JH-induced

SUBMITTER: Zhao W 

PROVIDER: S-EPMC12646218 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature