Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance.

ABSTRACT: Macroautophagy (hereafter autophagy) is essential for cells to respond to nutrient deficiency by delivering cytosolic contents to vacuoles for degradation via the formation of a multilayer organelle named an autophagosome. A set of autophagy-related (ATG) regulators are recruited to the phagophore assembly site for phagophore initiation, including its expansion and closure, and subsequent delivery into the vacuole. However, it remains elusive how the phagophore assembly is regulated under different stress conditions. Here, we described an uncharacterized Arabidopsis (Arabidopsis thaliana) ERC (ELKS/Rab6-interacting/CAST) protein family as an interacting partner of ATG8. ERC1 proteins translocate to the phagophore membrane and develop into ring-like autophagosomes upon autopha

SUBMITTER: Chung KK 

PROVIDER: S-EPMC12646234 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature