Land use drives drug resistance in an airborne human fungal pathogen.

ABSTRACT: Humans are exposed to the mold Aspergillus fumigatus via inhalation, and infections are increasingly resistant to triazole-class antifungals. Ecologically, this fungus is a ubiquitous saprotroph found in terrestrial environments. Although triazole-resistant A. fumigatus is found in large quantities in specific agricultural environments, it is not clear how much these contribute to the overall exposure of individuals to antifungal resistance. Triazoles are also used to protect a wide range of products unrelated to agriculture, and therefore, it could not be excluded that the resistance observed in agricultural settings may be the result of selection beyond agricultural sources. In the case of A. fumigatus, genomics cannot reliably link resistant isolates to specific environmental sources. T

SUBMITTER: Kortenbosch HH 

PROVIDER: S-EPMC12646274 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature