Episodic memory involves transient and sparse connectivity aligned to both internal and external events.

ABSTRACT: Episodic memory depends on the coordination of local processing, indexed by high-frequency broadband (HFB) activity, with global organization, indexed by theta oscillations. However, theta and HFB exhibit asynchronous timing, raising the question of how results of local processing are communicated. Using intracranial EEG in patients performing a recognition memory task, we examined this coordination across medial temporal (MTL) and prefrontal (PFC) regions. HFB peaks occurred earlier in the MTL than in the PFC. Contrasting analyses were anchored either to these internally driven HFB peaks or to the external event of stimulus presentation. We discovered three key results. First, the role of the PFC changed from encoding to retrieval. Specifically, PFC-MTL theta connectivity was aligned with

SUBMITTER: Dede AJO 

PROVIDER: S-EPMC12646405 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature