Mitochondrial targeting by measles virus nucleoprotein modulates viral spread in human airway epithelium.

ABSTRACT: Measles is the most infectious human respiratory virus: on average, one individual with measles infects 12-18 susceptible people in a population without immunity. However, how measles virus (MeV) establishes infection in the human respiratory epithelium is insufficiently understood. Since our analyses of MeV infections of well-differentiated primary human airway epithelial cells (HAE) revealed perturbations of mitochondrial gene expression, we tested mitochondrial function. MeV replication disrupted mitochondrial membrane potential and induced superoxide production. This resulted in cGAS-dependent interferon-stimulated gene expression without interferon induction. We then assessed by differential centrifugation whether MeV replicates in mitochondrial proximity. Indeed, MeV proteins and gen

SUBMITTER: Durnell-Bettis LA 

PROVIDER: S-EPMC12646431 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature