Obsessive-compulsive personality disorder in radically open dialectical behavior therapy for treatment-refractory depression.

ABSTRACT: Obsessive-compulsive personality disorder (OCPD) is commonly comorbid with major depressive disorder, and their comorbidity is associated with worsened outcomes and treatment refraction. Radically open dialectical behavior therapy (RO DBT) is a novel transdiagnostic psychosocial intervention. RO DBT targets OCPD-related traits (e.g., maladaptive perfectionism, inflexibility) and has been theorized as an OCPD treatment. This study examined RO DBT efficacy for treatment-refractory depression (TRD), with and without comorbid OCPD. RefraMED was a multisite randomized controlled trial of treatment as usual (TAU) versus RO DBT + TAU for TRD (N = 250). In this secondary data analysis, linear regression predicted 7-month (end of treatment) and 12-month (follow-up) symptoms, controlling for

SUBMITTER: Steinhoff MF 

PROVIDER: S-EPMC12646503 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature