Innovative engineering approaches to model host-microbiome interactions in vitro.

ABSTRACT: The human microbiome plays a critical role in health and disease. Disruptions in microbiota composition or function have been implicated not only as markers but also as drivers of diverse pathologies, creating opportunities for targeted microbiome interventions. Advancing these therapies requires experimental models that can unravel the complex, bidirectional interactions between human tissue and microbial communities. This scoping review examines emerging engineering approaches to design in vitro platforms that successfully integrate host and microbial components to model these interactions. Compared to traditional in vitro and in vivo approaches, these advanced microphysiological systems offer greater experimental control, human-specific biology, and reduced cost and ethical concerns. He

SUBMITTER: Mancera Azamar KM 

PROVIDER: S-EPMC12646538 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature