Age-Dependent Contributions of Rare and Common Genetic Variation in Atrial Fibrillation.

ABSTRACT:

Background

Genetic variation contributes to atrial fibrillation (AF), but its impact may vary with age. The All of Us Research Program contains whole-genome sequencing of data from 100 574 adult participants with linked electronic health records.

Methods

We assessed clinical, monogenic, and polygenic associations with AF in a cross-sectional analysis, stratified by age: <45 years (n=22 290), 45 to 60 years (n=26 805), and >60 years (n=51 659). AF was defined as ≥2 Systematized Nomenclature of Medicine-Clinical Terms codes on separate days. We identified pathogenic/likely pathogenic variants in 145 cardiac genes with dominant inheritance and calculated a previously established polygenic risk score. Adjusted for known clinical factors, multivariable analysis quantified

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12646633 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature