Magnetic Resonance Spectroscopy of Cystathionine and 2-Hydroxyglutarate in Brain Tumors.

ABSTRACT: Codeletion of chromosome 1p and 19q arms in a subset of gliomas has been shown to associate with the accumulation of cystathionine in the tumor. Here, we report the analyses of cystathionine and 2-hydroxyglutarate (2HG) in 38 biopsy-proven glioma patients, as measured with TE 97-ms point-resolved spectroscopy (PRESS) at 3 T. Following the confirmation of in-house calculated cystathionine basis signals in a phantom solution, LCModel spectral fitting was performed to decompose metabolite signals, and the millimolar concentrations of metabolites were estimated with reference to water. Cystathionine was estimated to be significantly higher in IDH mutated 1p/19q codeleted gliomas than in noncodeleted gliomas (1.4 ± 1.1 vs. 0.3 ± 0.4 mM; n = 15 and 14; p = 0.002). 2HG estimation was significantl

SUBMITTER: Choi C 

PROVIDER: S-EPMC12646717 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature