Marked enhancement of synergistic antioxidative activity of astaxanthin and curcumin by co-encapsulation in a liposomal formulation.

ABSTRACT: Natural antioxidants may help prevent oxidative stress-mediated aging. Astaxanthin (Asx) is a powerful antioxidant that has been used in various dietary supplements and cosmetics. Previously, we reported that combination of Asx with tocotrienol (T3) or capsaicin (Cap) exhibited synergistic antioxidative effects; however, the synergistic increase in activity was unremarkable. Herein, we employed curcumin (Cur) to more effectively enhance the antioxidant activity of Asx. The antioxidative activity of liposomes co-encapsulating Asx and Cur (Asx/Cur-lipo) showed effective synergism (activity increase of ~2). A shift in peak absorption suggested intermolecular interactions between Asx and Cur. Since synthetic Asx is a mixture of various stereoisomers, we examined the effect of Asx stereochemist

SUBMITTER: Yamasaki M 

PROVIDER: S-EPMC12646837 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature