Gymnemantoside A Ameliorates Steroid-Induced Skeletal Muscle Atrophy via Bridging Glucocorticoid and Insulin Receptor Signalling.

ABSTRACT:

Background

Skeletal muscle atrophy is a common condition caused by numerous factors, such as aging (termed sarcopenia), disease (e.g., cancer cachexia) or specific medications (such as glucocorticoids). There is no FDA-approved drug for treating skeletal muscle atrophy. Previously, clinical studies had highlighted the anti-diabetic properties of Gymnema inodorum extract, an indigenous medicinal plant and functional food in Thailand. However, these studies did not identify the active compound(s) responsible for its therapeutic effects. This research aimed to identify safe natural product-derived compounds from clinically relevant plants such as Gymnema inodorum that bridge the connection between metabolic diseases and skeletal muscle atrophy.

Methods

Utilizing the dexamethaso

SUBMITTER: Park EJ 

PROVIDER: S-EPMC12646868 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature