Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potential.

ABSTRACT:

Background

Patients affected by heat stroke (HS) develop myocardial injury at an early stage and exhibit a significantly higher risk of death than those without myocardial injury.

Methods

We used WGCNA and myocardial tissue transcriptome sequencing to identify candidate DEGs associated with HS-induced myocardial injury. Immune infiltration and functional enrichment analyses were performed to investigate the correlation between candidate DEGs and immune cell populations and their biological functions. Protein-protein interaction (PPI) network analysis was used to identify hub genes. Clinical validation was performed through ELISA of blood samples from patients with HS, followed by construction of a hub gene-based prognostic nomogram. Additionally, the L1000FWD platform was us

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC12646939 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature