Infection Risk in Older Kidney Transplant Recipients: An Analysis in the Era of Expanded Age Limits.

ABSTRACT: The expansion of eligibility criteria has led to an increase in the age at kidney transplantation (KT), with consequences on the infection risk. We performed a prospective single-center cohort study of 712 patients undergoing KT between 2014 and 2022. Recipient age (median: 56.6 years [interquartile range: 43.2-68.5]) was analyzed by 10-year strata and dichotomized by thresholds (≥60, ≥70, ≥75 and ≥80). Univariable and multivariable regression models were constructed to assess the incidence of overall, bacterial and opportunistic post-transplant infection. In unadjusted analyses, each 10-year-increase was associated with overall (subdistribution hazard ratio [SHR]: 1.18; 95% confidence interval [CI]: 1.11-1.26), bacterial (SHR: 1.17; 95% CI: 1.09-1.26) and opportunistic infection (SHR: 1.2

SUBMITTER: Fayos M 

PROVIDER: S-EPMC12646964 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature