Regulatory effects of berberine on intestinal microecology in mice with ulcerative colitis.

ABSTRACT:

Background

Currently, therapeutic approaches for ulcerative colitis (UC), such as aminosalicylates, glucocorticoids, and biologics, exhibit certain efficacy but are hindered by limitations including side effects, high costs, or suboptimal responses. As a traditional Chinese medicine component, berberine (BBR) possesses anti-inflammatory properties and the ability to modulate the gut microbiota, with low toxicity, and may provide new directions for UC treatment in the future.

Methods

A mouse UC model was established via dextran sulfate sodium (DSS) induction, and dose-and time-dependent screening was performed to determine the optimal BBR dosage and intervention duration for subsequent experiments. The disease activity index (DAI) and colon length were measured. Colonic tissu

SUBMITTER: Xu X 

PROVIDER: S-EPMC12647005 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature