TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats.

ABSTRACT:

Introduction

Despite their association with brain disorders, the neurophysiological roles of the trace amine-associated receptors remain poorly understood. In humans, the genomic trace amine-associated receptor cluster comprises nine consecutive genes, six of which code for functional proteins (TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9). While homologues of the former three are known to regulate classical monoamines and neurogenesis, the functions of the latter three remain largely unknown. In this exploratory study, we demonstrate for the first time that TAAR9 plays a significant regulatory role in the monoaminergic systems of the rat.

Methods

We used qPCR to measure TAAR9 mRNA expression throughout the rat brain. Serotonin, dopamine, and their metabolite levels were

SUBMITTER: Zhukov IS 

PROVIDER: S-EPMC12647061 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature