Efficacy and safety of esketamine in patients undergoing painless gastrointestinal endoscopy: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Esketamine, an intravenous anesthetic with analgesic properties, is increasingly used as an adjunct in painless gastrointestinal endoscopy. This systematic review and meta-analysis evaluated the efficacy and safety of esketamine combined with sedatives for anesthesia in adults undergoing painless gastrointestinal endoscopy.

Methods

Eight databases (PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, Wanfang, VIP, SinoMed) were systematically searched from inception until April 20, 2025. Randomized controlled trials (RCTs) comparing esketamine adjunctive therapy against placebo/sedative-alone in adults (ASA I-II) were included. Primary efficacy outcomes were anesthesia onset time, recovery time, and sedative requirements. Primary safety outcomes included proced

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12647098 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature