Microbiome-metabolome dysbiosis of bronchoalveolar lavage fluid of lung cancer patients.

ABSTRACT:

Background

Recent studies indicate that microorganisms significantly influence lung cancer pathogenesis. This research explores the variations in microbiota and metabolites in the lower respiratory tract between lung cancer patients and individuals with benign pulmonary lesions to identify potential diagnostic biomarkers.

Methods

Two hundred eight patients undergoing bronchoscopy at Tianjin Cancer Institute & Hospital and Tianjin Chest Hospital from October 2022 to October 2023 were screened. Ninety-five bronchoalveolar lavage fluid (BALF) was collected for metagenomic sequencing and untargeted metabolomic analysis. Comparisons of microbial diversity, taxonomic composition, and metabolite profiles were conducted between groups with lung cancer and benign lung conditions.

SUBMITTER: Wang J 

PROVIDER: S-EPMC12647101 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature