Metabolomic and lipidomic atlas of human hair across its length.

ABSTRACT: The stable structure and growth cycle of human hair enables the accumulation of both endogenous and exogenous compounds, making hair an ideal matrix for long-term profiling. However, its exact molecular composition, shaped by root-to-tip variations, remains poorly understood. Here, we present a metabolome and lipidome atlas of human hair originating from a healthy cohort. The Human Hair Atlas maps over 1200 unique molecular species and highlights compounds prone to significant longitudinal variations. Metabolite and lipid levels vary by up to 50% along the length of the hair, underscoring the importance of accounting for segmental differences. We categorized 122 molecules as exposome-related compounds, primarily from personal care products, facilitating biological interpretation. The Human

SUBMITTER: van de Lavoir M 

PROVIDER: S-EPMC12647130 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature