A homolog of methionine γ-lyase is required for biofilm development in the cyanobacterium Synechococcus elongatus.

ABSTRACT: Bacterial type IV pilus assembly systems are involved in diverse functions including motility, adhesion and DNA uptake. Studies of the cyanobacterium Synechococcus elongatus sp. PCC7942 revealed that this machinery is also involved in suppression of biofilm formation: inactivation of components of this complex results in robust biofilm development. EbsA, a unique component of cyanobacterial type IV pilus assembly complexes, immunoprecipitates with a homolog of methionine γ-lyase (MGL). Here we demonstrate that MGL is required for biofilm development. Based on immunoprecipitation experiments using MGL as a bait, we suggest that this enzyme associates with a large enzymatic hub and with the translation machinery. Inactivation of mgl in the biofilm-forming mutant pilBΩ abrogates biofilm forma

SUBMITTER: Zecharia E 

PROVIDER: S-EPMC12647202 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature