Intravenous anesthetic propofol suppresses T cell-dependent antibody production in mice.

ABSTRACT:

Purpose

General anesthesia combined with surgery is thought to suppress the immune system. However, few studies have examined the effects of anesthetics alone on humoral immunity. In this study, we aimed to investigate the effects of the intravenous anesthetic propofol on antibody production after immunization and the underlying mechanisms in mice.

Methods

Mice were immunized with 4-hydroxy-3-nitrophenylacetyl (NP) hapten-conjugated keyhole limpet hemocyanin (NP-KLH), a T cell-dependent antigen, or NP hapten-conjugated Ficoll (NP-Ficoll), a T cell-independent antigen, followed by treatment with propofol, or PBS or intralipid as controls, for five consecutive days. The mice were re-immunized, and antibody production and immune cell subsets were evaluated. The effects of propo

SUBMITTER: Hiraoka S 

PROVIDER: S-EPMC12647247 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature