Contribution of white matter microstructure to diffusion tensor image analysis along perivascular space in obstructive sleep apnea.

ABSTRACT:

Purpose

We aimed to evaluate whether the ALPS index derived from diffusion tensor image analysis along the perivascular space (DTI-ALPS) is influenced by white matter fibres within the analysis region, particularly commissural fibres from the corpus callosum that traverse this area in psychiatric patients with suspected obstructive sleep apnea (OSA). We also investigated associations between diffusion-based parameters, sleep-related data, and neurofluid-related imaging metrics.

Methods

Fifty participants with OSA underwent brain magnetic resonance imaging and polysomnography, including diffusion tensor and structural sequences. Among them, 8 participants had no psychiatric comorbidities, while the remaining 42 had various psychiatric disorders in addition to OSA. Diffusion-b

SUBMITTER: Taoka T 

PROVIDER: S-EPMC12647286 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature