PKCγ-mediated Phosphorylation of Mtss1 Regulates the Dendritic Outgrowth and Spine Development of Cerebellar Purkinje Cells.

ABSTRACT: Protein kinase C gamma (PKCγ) is a signalling protein expressed in Purkinje cells (PCs) of the cerebellum. It is involved in regulating synapse formation and PC dendritic development through phosphorylation of target proteins that control cytoskeleton dynamics and PC dendritic morphology. Mutations in the protein kinase C gamma gene cause spinocerebellar ataxia 14 (SCA14), an autosomal dominant neurodegenerative disease leading to motor deficits and cognitive decline. The molecular targets of PKCγ and its interaction with cytoskeletal regulators are not yet well understood. Using a PKCγ mutant mouse line (PKCγ-A24E), which expresses a constitutively active PKCγ causing an SCA14-like phenotype, we identified Metastasis suppressor protein 1 (Mtss1) as a PKCγ molecular target involved in PC d

SUBMITTER: Torrents-Sole P 

PROVIDER: S-EPMC12647342 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature