CXCL13 as a Biomarker of Complex Common Variable Immunodeficiency.

ABSTRACT:

Background

Common Variable Immunodeficiency (CVID) is a group of heterogeneous disorders with common denominators of impaired antibody production and function, and recurrent infections. Currently, prognostic biomarkers for CVID are limited. CXCL13 is a critical regulator of germinal centre responses and antibody production, with T follicular helper (Tfh) cells as a major source, and acts as a potent B cell chemoattractant. Serum levels of CXCL13 are increased in chronic inflammatory conditions and malignancy.

Objectives

We aimed to explore whether serum CXCL13 levels are altered in CVID and whether they can categorise the patients based on their clinical and immune phenotype.

Methods

We compared the serum levels of CXCL13 between CVID and healthy donors (HD) and assoc

SUBMITTER: Karafotias I 

PROVIDER: S-EPMC12647345 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature