CAR-DC combined with CAR-T therapy for relapsed/refractory acute myeloid leukaemia: Research progress and future perspectives.

ABSTRACT: Acute myeloid leukaemia (AML) remains the most common type of leukaemia in adults. Despite advances in conventional therapies, high relapse rates persist, underscoring the need for novel approaches such as chimeric antigen receptor T (CAR-T) cell therapy. C-type lectin-like molecule-1 (CLL1)-targeted CAR-T emerges as a promising treatment for relapsed/refractory (R/R) AML. Although approximately 70% patients achieved remission, only a subset achieved minimal residual disease-negative remission, which still has much room for improvement. The main reasons for the failure of CLL1 CAR-T-cell therapy include: (1) persistence of CLL1-negative AML cells persist due to antigen escape; (2) downregulation of interleukin (IL)-12 and other cytokines by the immunosuppressive tumour microenvironment (TM

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12647367 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature