African swine fever virus L11L interferes with antiviral responses by targeting the IRF3 and PKR.

ABSTRACT: The African Swine Fever Virus (ASFV) is a large, complex DNA virus that infects wild boars and domestic pigs. It causes African Swine Fever (ASF), an intense and often fatal disease with 100% fatality rate. After infection, ASFV employs specific viral proteins to enhance pathogenicity. However, the functions of many of these proteins remain unknown. This study investigated the molecular mechanism by which ASFV L11L evades type I interferon (IFN) pathway and protein kinase R (PKR)-mediated antiviral responses. Interestingly, we found that L11L interacts with interferon regulatory factor 3 (IRF3), specifically with the S396 and S398 amino acids, leading to the inhibition of the phosphorylation of IRF3 by Tank-binding kinase 1 (TBK1). Consequently, this interaction impedes IRF3 dimerization,

SUBMITTER: Haluwana DK 

PROVIDER: S-EPMC12647417 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature