Systematic Review and Meta-Analysis of the Management of Relapsed Germ Cell Tumours Following Cisplatin-Based Chemotherapy.

ABSTRACT:

Introduction

Salvage treatment options after cisplatin-based chemotherapy for germ cell tumours (GCT) are either conventional-dose chemotherapy (CDCT) or high-dose chemotherapy (HDCT). However, the optimal sequencing of these strategies remains debated owing to limited comparative data guiding the choice of first-line salvage. Here, we evaluated the efficacy and safety of CDCT and HDCT, focusing on survival rates, objective response rate (ORR) and treatment-related deaths (TRD).

Methods

The protocol was registered on PROSPERO (CRD42024526637). Three databases were searched and reference lists were manually screened. Two reviewers independently screened articles and extracted data, with quality and bias assessed using Risk of Bias in Non-randomised Studies of Interventions (R

SUBMITTER: Abdul Aziz N 

PROVIDER: S-EPMC12647420 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature