Elevated expression of SIGLEC8 in skin cutaneous melanoma predicts better prognosis associated with hematopoietic cell lineage pathway.

ABSTRACT:

Background

Cutaneous melanoma (SKCM) is becoming more common. Current prognostic markers-TNM stage, BRAF mutation status, and tumor mutational burden (TMB)-do not offer precise predictions. Recent studies point to a key role for the tumor microenvironment. To date, we do not know how SIGLEC8 (a sialic acid-binding immunoglobulin‑like lectin) affects immune regulation or prognosis in SKCM.

Methods

We used logistic regression to link SIGLEC8 expression with clinical and pathological features. We then applied Cox regression and Kaplan‑Meier survival analysis to assess how these features relate to overall survival (OS). For differential genes, we performed Gene Ontology (GO) and KEGG enrichment tests by combining fold‑change thresholds with hypergeometric statistics. Finally, we

SUBMITTER: Li F 

PROVIDER: S-EPMC12647512 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature