Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis.

ABSTRACT:

Background

Optic neuritis (ON) is a common manifestation of multiple sclerosis and related disorders (MSRD) characterized by retinal neurodegeneration, including thinning of ganglion cell-inner plexiform layer (GCIPL). Compared to absolute values, inter-eye differences (IED) account for variation in baseline structure and function before ON.

Objectives

To determine retinal layer IED thresholds associated with multimodal visual dysfunction after unilateral demyelinating ON.

Methods

In this cross-sectional study, MSRD participants with and without a history of unilateral ON, and healthy controls underwent optical coherence tomography, best-corrected visual acuity, 2.5% and 1.25% low-contrast letter acuity (LCLA), standard automated perimetry, and color vision testing.

SUBMITTER: Subhi M 

PROVIDER: S-EPMC12647537 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature