Exploring the role of chitosan and curcumin-loaded chitosan nanoparticles against chronic toxoplasma infection in experimental mice.

ABSTRACT: Toxoplasma gondii infection remains a significant global health concern, promoting the urgent need for effective therapeutic strategies. This study aimed to evaluate the therapeutic potential of chitosan nanoparticles (CSNPs) and curcumin-loaded chitosan nanoparticles (Cur-CSNPs) against the chronic Toxoplasma gondii (ME49 strain) in an experimental mouse model. This achieved by investigating their ability to reduce parasitic load, oxidative stress, histopathological lesion, and to enhance the host immune response. Sixty female BALB/c mice were divided into five groups: infected untreated group, Spiramycin®-treated group, CSNPs-treated group, Cur-CSNPs-treated group, and negative control group. The Cur-CSNPs-treated group exhibited the lowest brain cyst counts, along with significant reduc

SUBMITTER: Khedr AA 

PROVIDER: S-EPMC12647587 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature