Serum zinc dynamics as a diagnostic and immunomodulatory biomarker in neonatal sepsis.

ABSTRACT: This study aimed to investigate serum zinc levels in term neonates with sepsis, evaluate its correlation with immune parameters, and assess zinc's diagnostic efficacy in identifying neonatal sepsis. A prospective cohort study was conducted, involving two groups: 52 neonates diagnosed with sepsis who were admitted to the neonatal intensive care unit (NICU) of our hospital between January 2022 and June 2023, and 50 healthy controls matched for gestational age and birth weight. Serum zinc levels, cytokine profiles, and C-reactive protein (CRP) were measured in both cohorts. No statistically significant differences were observed in baseline characteristics between the sepsis group (n = 52) and the healthy controls group (n = 50). Neonates with sepsis exhibited significantly lower serum zinc le

SUBMITTER: Huang L 

PROVIDER: S-EPMC12647643 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature