Dose standardization for transcranial electrical stimulation: an accessible approach.

ABSTRACT: Transcranial electrical stimulation (tES) is a widely used non-invasive brain stimulation technique. However, due to high inter-individual variability in the induced electric fields (E-fields), a fixed stimulation current delivers an inconsistent dose. We developed a dose standardization method without the requirement of participant-specific structural imaging and E-field modeling. Robust multiple linear regression models were trained to predict peak E-field strengths across 10 electrode montages and 418 healthy adults. These regression models predicted peak E-field strengths in unseen participants from accessible demographic and morphological parameters. Estimated peak E-field strength values were subsequently used to standardize tES dosages across our population. Additionally, we develop

SUBMITTER: Toth J 

PROVIDER: S-EPMC12647676 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature