Epigenetic signatures, age acceleration, and injury risk in elite female and male soccer players.

ABSTRACT: Physical activity has been extensively associated with epigenetic modifications. However, the potential contribution of DNA methylation patterns to sports injury susceptibility remains largely unexplored, particularly among high-performance athletes. Since methylation regulates genes involved in inflammation, tissue repair, and musculoskeletal function, altered methylation profiles may influence injury risk. Moreover, epigenetic clocks are increasingly used to assess vulnerability to clinical phenotypes, as accelerated epigenetic aging has been linked to various diseases. Here, we studied the DNA methylome of peripheral blood cells in 74 elite female and male soccer players with extensive non-contact injury follow-up. We aimed to explore alterations associated with increased injury risk an

SUBMITTER: Perez RF 

PROVIDER: S-EPMC12647692 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature