Integrative genomics characterizes HCC eRNAs for prognosis and targeted therapy.

ABSTRACT: Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality globally, exhibits limited diagnostic and therapeutic biomarkers despite its clinical significance. Emerging evidence has positioned enhancer RNAs (eRNAs) as pivotal regulators in tumorigenesis, prompting this study to systematically identify HCC-specific eRNA signatures and elucidate their functional relevance. Through integrative analysis of three independent cohorts (n = 115 tumor-normal pairs), we identified three eRNA biomarkers-CAP2e, COLEC10e, and MARCOe-exhibiting significant differential expression between HCC and adjacent tissues, with validation in The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset. Notably, these eRNAs demonstrated strong positive correlation with their host gene

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12647720 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature