Magnetic hyperthermia using iron oxide nanoparticles via LDDS suppressed lymph node and lung metastasis in a mouse model.

ABSTRACT: Lymph node (LN) metastasis remains a critical determinant of cancer progression and prognosis, yet surgical interventions result in adverse effects. In this preclinical study, we investigated a minimally invasive therapeutic approach combining magnetic hyperthermia (MH) with a lymphatic drug delivery system (LDDS) using iron oxide nanoparticles (Resovist^®). A custom-built MH device precisely regulated LN temperature at 45 °C. Using a mouse model (MXH10/Mo/lpr) of tumor-suspicious LN (ts-LN) metastasis, Resovist^® was intranodally administered, followed by MH treatment. This combination significantly suppressed tumor growth in ts-LN and reduced lung metastasis, with enhanced M1 macrophage polarization and antitumor immune responses. Histopathology confirmed tumor necros

SUBMITTER: Kuwahata A 

PROVIDER: S-EPMC12647774 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature