Fabrication of self-emulsifying lipid microstructure by stiffness-tunable mold for drug delivery applications.

ABSTRACT: Amphiphilic lipid formulations, such as self-emulsifying drug delivery systems, offer advantages for enhancing drug release control and expanding their applicability across various administration routes. By integrating microfabrication techniques with these lipid-based systems, additional functionalities such as controlled drug release can be introduced. This can broaden lipid's potential for advanced biomedical and pharmaceutical applications. However, lipids face major fabrication challenges due to their thermolability, solvent incompatibility, and poor mechanical properties. Here, we present a novel microfabrication route for self-emulsifying lipid drug delivery systems based on thermal imprinting of a stiffness-tunable mold, which stays inflexible during the thermal imprinting step and

SUBMITTER: Park J 

PROVIDER: S-EPMC12647786 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature