Antiproliferative effect of Filopaludina bengalensis fluid inducing apoptosis-necroptosis synergy with immunogenic remodelling in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) represents a highly aggressive phenotype of breast carcinoma, distinguished by unique metastatic patterns and poor prognosis driven by its immune microenvironment. Recent advances integrating anticancer agents with personalized immunotherapies are emerging as promising avenues for TNBC management. Freshwater molluscs, though primarily consumed as nutraceuticals and less explored scientifically, hold promising therapeutic potential as immunomodulatory, natural anticancer agents. In the current investigation the anticancer potential of the extrapallial fluid of Filopaludina bengalensis (FBF), a widespread mollusca in south-eastern India, was evaluated against TNBC, exploring its underlying molecular mechanism. Dose-dependent antiproliferative effect in fl

SUBMITTER: Mangal S 

PROVIDER: S-EPMC12647806 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature